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YWHAZ gene

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta

Key facts

Official symbol
YWHAZ
Full name
YWHAZ
Chromosome
8
Map location
8q22.3
Organism
Homo sapiens
NCBI Gene ID
7534
Also known as
14-3-3-zeta, HEL-S-3, HEL-S-93, HEL4, KCIP-1, POPCHAS

Function summary

This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse, rat and sheep orthologs. The encoded protein interacts with IRS1 protein, suggesting a role in regulating insulin sensitivity. Several transcript variants that differ in the 5' UTR but that encode the same protein have been identified for this gene. [provided by RefSeq, Oct 2008].

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Data source: NCBI Gene · alsesAI Gene Library